|
rs7873784
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We hypothesize that additional functional PU.1 site may increase TLR4 expression in individuals carrying minor C variant of rs7873784 and modulate the development of certain pathologies, such as rheumatoid arthritis and type-2 diabetes mellitus.
|
31785408 |
2020 |
|
rs7873784
|
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We hypothesize that additional functional PU.1 site may increase TLR4 expression in individuals carrying minor C variant of rs7873784 and modulate the development of certain pathologies, such as rheumatoid arthritis and type-2 diabetes mellitus.
|
31785408 |
2020 |
|
rs2149356
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.
|
31772831 |
2019 |
|
rs2149356
|
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.
|
31772831 |
2019 |
|
rs1927911
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.
|
31772831 |
2019 |
|
rs1927911
|
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, there was no significant difference in the distribution of theother6 SNPs of TLR4 between groups of none/mild -periodontitis and moderate/severe-periodontitis subjects.When combined with <i>P. gingivalis</i> infection, rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG) were independent risk factors of chronic periodontitis.
|
31772831 |
2019 |
|
rs4986791
|
|
Osteitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The findings suggest that TLR4 has no significant role in the emergence of osteitis after newborn BCG vaccination, but the variant genotypes of the TLR4 rs4986790 and rs4986791 may impair the production of pro-inflammatory cytokines.
|
31755594 |
2019 |
|
rs4986790
|
|
Osteitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The findings suggest that TLR4 has no significant role in the emergence of osteitis after newborn BCG vaccination, but the variant genotypes of the TLR4 rs4986790 and rs4986791 may impair the production of pro-inflammatory cytokines.
|
31755594 |
2019 |
|
rs4986791
|
|
Urinary tract infection
|
|
0.040 |
GeneticVariation
|
BEFREE |
Due to the small number of available literatures, no meaningful conclusion can be drawn regarding the relationship between TLR4 (rs4986791) and the risk of urinary tract infections in general.
|
31749314 |
2020 |
|
rs4986790
|
|
Urinary tract infection
|
|
0.040 |
GeneticVariation
|
BEFREE |
Nevertheless, our meta-analysis shows that in Asian populations, TLR4 (rs4986790) may be associated with risk of urinary tract infection.
|
31749314 |
2020 |
|
rs4986791
|
|
Recurrent urinary tract infection
|
|
0.020 |
GeneticVariation
|
BEFREE |
Due to the small number of available literatures, no meaningful conclusion can be drawn regarding the relationship between TLR4 (rs4986791) and the risk of urinary tract infections in general.
|
31749314 |
2020 |
|
rs4986790
|
|
Recurrent urinary tract infection
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nevertheless, our meta-analysis shows that in Asian populations, TLR4 (rs4986790) may be associated with risk of urinary tract infection.
|
31749314 |
2020 |
|
rs4986791
|
|
Glaucoma, Primary Open Angle
|
|
0.040 |
GeneticVariation
|
BEFREE |
The minor alleles of rs4986791 and rs2149356 within TLR4 gene, interaction between rs2149356 and alcohol drinking were all associated with increased POAG risk.
|
31697008 |
2020 |
|
rs2149356
|
|
Glaucoma, Primary Open Angle
|
|
0.040 |
GeneticVariation
|
BEFREE |
The minor alleles of rs4986791 and rs2149356 within TLR4 gene, interaction between rs2149356 and alcohol drinking were all associated with increased POAG risk.
|
31697008 |
2020 |
|
rs4986791
|
|
Infection caused by Helicobacter pylori
|
|
0.040 |
GeneticVariation
|
BEFREE |
The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.
|
31690518 |
2019 |
|
rs4986790
|
|
Infection caused by Helicobacter pylori
|
|
0.040 |
GeneticVariation
|
BEFREE |
The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.
|
31690518 |
2019 |
|
rs4986790
|
|
Gastritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.
|
31690518 |
2019 |
|
rs4986791
|
|
Gastritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.
|
31690518 |
2019 |
|
rs4986791
|
|
Infection in children
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objectives of the study were to evaluate the associations between both TLR4 rs4986790 and rs4986791 gene polymorphisms and H. pylori infection in children with gastritis.
|
31690518 |
2019 |
|
rs4986790
|
|
Infection in children
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objectives of the study were to evaluate the associations between both TLR4 rs4986790 and rs4986791 gene polymorphisms and H. pylori infection in children with gastritis.
|
31690518 |
2019 |
|
rs10759932
|
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of rs10759932 and rs2737190 in TLR4 are significantly related to both COPD and PTB but with inverse effects.
|
31640653 |
2019 |
|
rs10759932
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of rs10759932 and rs2737190 in TLR4 are significantly related to both COPD and PTB but with inverse effects.
|
31640653 |
2019 |
|
rs5030728
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, The peak of risk of HCC was observed with allele C of rs3804099 of TLR2 and C allele of rs10116253 TLR4 (<i>p</i> < 0.001).A strong association was found with allele T of rs1816702 of TLR2 and allele A of rs5030728 of TLR4 in non responder group in comparison to responders (<i>p</i> < 0.001).
|
31615295 |
2019 |
|
rs4986790
|
|
Asthma
|
|
0.080 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.
|
31530336 |
2020 |
|
rs4986790
|
|
IgE-mediated allergic asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.
|
31530336 |
2020 |